In the Bioinformatics Laboratory, we mainly deal with protein sequences and their three-dimensional structures. There are two main directions of our research:
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Methods development. We aim to improve computational methods for sequence comparison and protein structure prediction (mainly in comparative modeling), as well as methods for assessing protein structure quality.
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Application of computational methods to biological problems. Most often, we use computational methods to characterize the structure and interactions of both individual proteins and their complexes. In these studies, we tend to focus on proteins/protein complexes that function in DNA metabolism, including DNA replication, recombination, and repair. Our objective is to make inferences regarding structural and functional features, molecular mechanisms, interactions, and related phenomena that can be experimentally tested. Most of such studies are joint collaborations with experimentalists.