We are a Cellular Electrophysiology Laboratory affiliated with the Department of Neurobiology and Biophysics at the Institute of Biosciences, Vilnius University Life Sciences Center. Using the patch-clamp electrophysiology technique, we study electrical signals in mouse brain neurons and transfected HEK293 cell lines.
Currently, our research is organized into three main directions:
• Neuronal development – we investigate how the electrophysiological properties of hippocampal neurons and network connectivity emerge after birth, and how these processes are influenced by sex and synaptic pruning.
• Ion channel mutations – we study how disease-associated mutations in the KCNQ1 ion channel affect its function and explore ways to mitigate their impact.
• Modelling synaptic plasticity – using mathematical modelling, we analyze how feedback mechanisms involving nitric oxide and other signalling pathways contribute to long-term synaptic strengthening, which underlies memory formation.
Our goal is to understand the nervous system from the molecular to the network level by integrating experimental approaches with theoretical modelling.
