The doctoral project is dedicated to the engagement of natural nanoparticles to solve bioengineering and biomedical problems. Viruses are natural supramolecular structures designed by nature for genome packaging and delivery. The use of virions in biomedicine and - to a lesser extent - nanotechnology has received a lot of attention in the last decade. Current advances in these areas are neither sufficient nor meet the needs of healthcare and engineering. During the preparation of supramolecular derivatives of programmable shape, spatial structures created by nucleic acid bases dominate, characterized exclusively by the limited set of properties of these biopolymers. The proteinaceous structures will display an expanded range of functions, while the combination of both biopolymers will significantly expand the horizons of application. To alleviate the shortage for safe, universal and multipurpose cargo delivery system, we propose to employ intrinsic yeast viruses for the development of bionano scaffolds with various target specificities. During the execution of the project, a multifaceted program of yeast virus capsid engineering will be carried out in order to prepare nanostructures with novel properties. The development of bionanoparticles compatible with the human body opens up new opportunities in bioengineering and the production of smart materials with hitherto unseen properties. The special value of such systems is the satisfaction of various fundamental needs of biotechnology and medical engineering, realized within the scope of one principal system.