Technology licensing
Patent portfolio available for licensing
Breakthrough life-science inventions from VU Life Sciences Center, organised by technology area and patent family — from CRISPR-Cas gene editing and single-cell genomics to methyltransferase tools and drug-discovery chemistry.
23Patented inventions 5Technology areas US·EU·JPGranted jurisdictions
🧬 CRISPR-Cas gene editing & genome engineering 6
RNA-directed DNA cleavage by the Cas9-crRNA complex
Foundational CRISPR-Cas9 technology — programmable, RNA-guided cleavage of DNA at a chosen sequence; the basis of modern genome editing.
Programmable RNA shredding by the type III-A CRISPR-Cas system
Type III-A CRISPR-Cas system (S. thermophilus) reprogrammed to target and degrade specific RNA molecules.
Targeted RNA knockdown and knockout by type III-A Csm complexes (Csm-RAAi)
Csm effector complexes for programmable, targeted RNA knockdown and knockout.
Production of cyclic adenylates as allosteric regulators
Cyclic oligoadenylate signalling molecules that switch on CRISPR type III immune effectors.
Identification & characterization of double-strand break sites
Methods to map and characterise genome-editing double-strand break sites — editing safety and off-target analysis.
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CRISPR nuclease off-target detection by sequencing (CROFT-Seq)
Sequencing-based assay to detect CRISPR nuclease off-target activity across the genome.
🔬 Single-cell genomics & microfluidics 4
Systems and methods for barcoding nucleic acids
Tagging nucleic acids with molecular barcodes for high-throughput single-cell analysis.
Biomimetic fluid processing
Microfluidic, droplet-based platform for processing biological samples at scale.
Synthesis of DNA particles and use thereof
Synthesis of DNA particles (e.g. barcoded beads) and their use in genomics workflows.
Encapsulation & multi-step processing of biological samples
Microfluidic encapsulation and multi-step processing of single cells and samples.
🔬 Epigenetics & methyltransferase tools 3
Derivatization of biomolecules using methyltransferases
Covalent coupling of non-cofactor compounds to biomolecules via methyltransferases — labelling and functionalisation.
Conversion of alpha-hydroxyalkylated residues using methyltransferases
Methyltransferase-based conversion of modified residues for epigenetic analysis.
S-adenosyl-L-methionine analogues with extended activated groups
Novel SAM cofactor analogues enabling methyltransferase-mediated group transfer and labelling.
🧺 Nucleic-acid synthesis, sequencing & molecular tools 4
Nucleic acid production and sequence analysis
Methods for producing nucleic acids and analysing their sequences.
Analysis of single-stranded RNA
Techniques for the analysis of single-stranded RNA.
N4-modified cytidine nucleotides and their use
Modified cytidine nucleotides and their applications in molecular biology.
Catalytic biomolecule activity recording into DNA sequence
Recording biomolecule catalytic activity into a DNA sequence — molecular recording / synthetic biology.
💊 Drug discovery & therapeutic proteins 6
Fluorinated benzenesulfonamides as carbonic anhydrase inhibitors
Fluorinated benzenesulfonamide inhibitors of carbonic anhydrase for drug development.
Selective inhibitors of carbonic anhydrase
Isoform-selective carbonic anhydrase inhibitors as therapeutic candidates.
Benzimidazo-thiadiazole sulfonamides as carbonic anhydrase inhibitors
A further carbonic anhydrase inhibitor chemotype and its synthetic intermediates.
Thiadiazoles as inhibitors of the HSP90 chaperone
5-Aryl-thiadiazole small-molecule inhibitors of the HSP90 chaperone — anticancer candidates.
Monoclonal antibodies using chimeric VLPs
Production of monoclonal antibodies using chimeric virus-like particles.
Production of selenoproteins (selprot)
A method for the recombinant production of selenoproteins.
Patent numbers link to Google Patents. Technical drawings are sourced from the corresponding patent publications.
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