Systems` biology

Course unit title

Scientific direction

Scientific code

Faculty

Department (s)

Systems` biology

Biochemistry N 004

Life Sciences Center

Institute of Biosciences

Total number of credits

Mode of studies

Number of credits

Mode of studies

Number of credits

Lectures

0

Consultations

3

Self-studies

7

Seminars

1

Aims of course

The aims of Systems Biology course – development of understanding of cell as integrated system, knowledge on investigation methods, applied and fundamental aspects, leading to integrating  capability for the understanding of a research object.

Main topics

Systems Biology object and premises. Object definition, need and premises, perspectives of development.

DNA sequencing metods and milestones. Description and sources for DNA sequencing. Pre-industrial sequencing. Modern methods and future developments. Significance of massive DNA sequencing.

Epigenetics. Description of an object. Epigenetics aspects and components. Significance and perspectives.

Transcriptomics. Description of an object. Methods in transcriptomics. Application and future perspectives.

Proteomics. Object and methods. Premises of proteomics. Principles and methods. Application, challenges, perspectives.

Bioinformatics in Systems Biology. Object of Bioinformatics. Application in Systems Biology. Premises of Bioinformatics. Research levels and modelling issues. Bioinformatics resources.

Functional analysis of a cell. Interacting cell. Raise of Cell Theory. Content and significance of Cell Theory. Inside the cell.

Main literature

• Eberhard O. Voit. A First Course in Systems Biology. Garland Science, Taylor & Francic Group, LLC. ISBN 978-0-8153-4467-4. 2013.
• Edda Klipp et al. Systems Biology. Wiley-VCH Verlag GmbH & Co. KGaA ISBN: 978-3-527-31874-2. 2009.
• Bernhard O. Palsson. Systems Biology. Properties of Reconstructed Networks. Cambridge University Press. ISBN: 978-0-521-85903-5. 2010.
• Trends in Biochemical Sciences, Trends in Cell Biology, Nature Reviews, Science  2010-2020.

Assessment strategy

Assessment criteria

Public presentation

Presentation duration – one academic hour (45 min) and 15 min for questions. Presentation covers 5-10 papers or reviews.

Saulius Serva

Approved by the Council of Doctoral School of Life Sciences Center No (4.10)600000-KT-… on the 14th of October 2021

Chairman dr. Daiva Baltriukienė