Membrane Lipid Therapy is an innovative therapeutic approach focused on targeting and modulating the lipid components of cellular membranes to treat various diseases. This strategy relies on the principle that membrane lipid composition and organization alterations can influence membrane proteins' structure and function, impacting cellular processes such as intracellular signaling, gene expression, and enzymatic activity. By reconfiguring membrane properties, membrane lipid therapy aims to correct pathological states, offering potential treatments for conditions like cancer, neurodegenerative disorders, cardiovascular diseases, and inflammation. During PhD studies, the candidate will test a library of synthetic fatty acids that modify the composition and fluidity of the cell membrane to interfere with the activity of membrane-associated receptors responsible for disease processes, including tumor growth. This analysis aims to identify potential candidates capable of increasing intracellular delivery of common chemotherapeutic drugs, enhancing their cytotoxic potential. The screening will be facilitated by the use of tethered bilayer lipid membranes, an artificial model, emerging as a novel platform technology for drug discovery and development.
Mokslinis vadovas / Supervisor: dr. Giulio Preta
Konsultantė / Consultant: dr. Rima Budvytytė
Kontaktai / Contacts:
Programme: Biochemistry N 004