Name and Surname of the Supervisor: Simona Steponkienė
Institution (Company), Department: National Cancer Institute, Biomedical Physics Laboratory
Preliminary Topic: Synthesis and characterization of Chlorin e6 nanoparticles and evaluation of their theranostic properties in cancer cells
Short Description of the Internship Work: Research aim – to develop a biocompatible Chlorin e6 nanodrug that is stable, accumulates in cancer cells, and induces cancer cell death only upon irradiation with 650 nm visible light.
To achieve this aim, the following objectives will be carried out:
1) Synthesis of Chlorin e6 nanoparticles (Ce6-Nano) using phospholipids;
2) Assessment of Ce6-Nano stability using absorption and fluorescence spectrometry as well as dynamic light scattering;
3) Evaluation of Ce6-Nano biocompatibility using the XTT cell viability and proliferation assay;
4) Evaluation of Ce6-Nano accumulation and effects on cancer cells using confocal microscopy and flow cytometry.
Qualification Requirements (Degree): BSc, MSc
Application Deadline: 2025-12-31
Additional Comments: Biophysics, biochemistry, molecular biology and other scientific fields related to the study.