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Dalius Ratautas  

Phone: +370 607 86164
Email: 

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Research Interests: Scientific research interests involve the development of biosensors towards clinical and environmental applications, as well as fundamental research on biocatalysis.

Biosensors for DNA detection. Single-nucleotide polymorphisms (SNPs) are common variations in the human genome, and over 60 million SNPS are known to date. Many SNPs are clinically related, and their identification is important. The most recent research involves the development of biosensors for SNP detection, with a particular focus on pharmacogenetic SNPs.
Click here to read more about the latest project.

Biosensors for nucleases and peptidases. Nucleases and peptidases, enzymes that cleave nucleic acids and peptides, respectively, have recently been reported as biomarkers for various diseases. For example, MRE11 nuclease is directly related to breast cancer, while skin peptidases could showcase the development of various skin diseases. Recent research involved harnessing the diagnostic potential of those enzymes.

Biosensors for small metabolic molecules. Glucose, ethanol, formaldehyde, and amino acids are common metabolites that are important in both clinical and environmental monitoring. Recent research is focused on developing biosensors for the detection of L-amino acids, applicable in clinical settings to monitor L-amino acids in intensive care patients.

Fundamental research on (bio)catalysis. Nanoparticles can mimic enzymes and exhibit various catalytic activities. How? Research focuses on investigating how metallic nanoparticles can mimic enzymes, providing a mechanistic explanation for catalysis.
Present Position: Senior Researcher
Education:
PhD in Biochemistry
Publications:

LABT_LMAVB 
ORCID

Five most important publications (full publication record ORCID):

1. J. Gineitytė, S. Serapinas, D. Ratautas. Electrochim. Acta 2024, 507, 145146.
DOI: https://doi.org/10.1016/j.electacta.2024.145146
2. K. Ratautė and D. Ratautas. Biosensors 2024, 14, 5.
DOI: https://doi.org/10.3390/bios14010005
3. M. Miškinis, E. Ramonas, V. Gurevičienė, J. Razumienė, M. Dagys, D. Ratautas. ACS Sens. 2022, 7, 11, 3352–3359.
DOI: https://doi.org/10.1021/acssensors.2c01342
4. S. Serapinas, J. Gineitytė, M. Butkevičius, R. Danilevičius, M. Dagys and D. Ratautas. Biosens. Bioelectron. 2022, 213, 114475.
DOI: https://doi.org/10.1016/j.bios.2022.114475
5. E. Ramonas, M. Butkevičius, S. Shleev, M. Dagys and D. Ratautas. Sens. Actuators B Chem. 2022, 367, 132054.
DOI: https://doi.org/10.1016/j.snb.2022.132054

Projects and Grants:

Principal investigator (PI):

• Development of an electrochemical biosensor for the detection of single nucleotide polymorphisms (2023–2025), funded by Research Council of Lithuania (S-MIP-23-127), grant budget – €149899
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• Development of a bioelectrochemical L-amino acid - urea analyzer for monitoring of intensive care patients (2023–2024), funded by Research Council of Lithuania (S-TPP-23-3), grant budget – €149986

• Biosensor Platform for Rapid, Inexpensive and Accurate Determination of Amino Acid Concentrations for Patients undergoing Renal Replacement Therapy (2020–2023), funded by European Regional Development Fund (ERDF) (01.2.2-LMT-K-718-03-0005), grant budget – €699478

Languages: Lithuanian (native), English