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Dalius Ratautas  

Phone: +370 607 86164
Email: 

ORCID 
LinkedIn

 

Research Interests: Scientific research interest involve development of biosensors towards clinical and environmental application as well as fundamental research on biocatalysis.

Biosensors for DNA detection. Single nucleotide polymorphisms (SNPs) are common variation in human genome and over 60 million SNPS are known to date. Many SNPs are clinically-related and their identification is important. Most recent research involve biosensor development for SNP detection, especially focusing of pharmacogenetic SNPs.
Click here to read more about the latest project.

Biosensors for nucleases and peptidases. Nucleases and peptidases, enzymes that cleave nucleic acids and peptides, respectively, recently are reported as biomarker for various diseases. For example, MRE11 nuclease is directly related with breast cancer, while skin peptidases could showcase the development of various skin diseases. Recent research involved harnessing the diagnostic potential of those enzymes.

Biosensors for small metabolic molecules. Glucose, ethanol, formaldehyde, amino acids – are common metabolites important both in clinical as well as environmental monitoring. Recent research is focused on developing biosensors for L-amino acid detection applicable for clinical setting to monitor L-amino acids present in intensive care patients.

Fundamental research on (bio)catalysis. Nanoparticles can mimic enzymes and exhibit various catalytic activities. How? Research focuses on investigation how metallic nanoparticles could mimic enzymes and that is the mechanistic explanation of catalysis.
Present Position: Senior Research Associate
Education:
PhD in Biochemistry
Publications:

LABT_LMAVB 
ORCID

Five most important publications (full publication record ORCID):

1. J. Gineitytė, S. Serapinas, D. Ratautas. Electrochim. Acta 2024, 507, 145146.
DOI: https://doi.org/10.1016/j.electacta.2024.145146
2. K. Ratautė and D. Ratautas. Biosensors 2024, 14, 5.
DOI: https://doi.org/10.3390/bios14010005
3. M. Miškinis, E. Ramonas, V. Gurevičienė, J. Razumienė, M. Dagys, D. Ratautas. ACS Sens. 2022, 7, 11, 3352–3359.
DOI: https://doi.org/10.1021/acssensors.2c01342
4. S. Serapinas, J. Gineitytė, M. Butkevičius, R. Danilevičius, M. Dagys and D. Ratautas. Biosens. Bioelectron. 2022, 213, 114475.
DOI: https://doi.org/10.1016/j.bios.2022.114475
5. E. Ramonas, M. Butkevičius, S. Shleev, M. Dagys and D. Ratautas. Sens. Actuators B Chem. 2022, 367, 132054.
DOI: https://doi.org/10.1016/j.snb.2022.132054

Projects and Grants:

Principal investigator (PI):

• Development of an electrochemical biosensor for the detection of single nucleotide polymorphisms (2023-2025), funded by Research Council of Lithuania (S-MIP-23-127), grant budget – €149899
Click here to read more

• Development of a bioelectrochemical L-amino acid - urea analyzer for monitoring of intensive care patients (2023-2024), funded by Research Council of Lithuania (S-TPP-23-3), grant budget – €149986

• Biosensor Platform for Rapid, Inexpensive and Accurate Determination of Amino Acid Concentrations for Patients undergoing Renal Replacement Therapy (2020-2023), funded by European Regional Development Fund (ERDF) (01.2.2-LMT-K-718-03-0005), grant budget – €699478

Languages: Lithuanian (native), English 

 

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