Short Description: Compact coulometric Karl Fischer titrator for trace water content determination in liquids, solids and gases (10 µg – 200 mg absolute water, down to 0.001 %). Coupled with an 860 KF Thermoprep oven (up to 250 °C) for thermal sample preparation of substances that are insoluble, react with KF reagent or release water only upon heating.
Produser: Metrohm
Equipment Information:
The Metrohm 917 Coulometer is a compact all-in-one coulometric titrator for water content determination according to Karl Fischer. The operating module, touchscreen, stirrer and pump for rapid reagent exchange are integrated into one unit. Coulometry is an absolute method – no titer determination is required. This configuration uses a generator electrode without diaphragm, suitable for most samples that are highly soluble in alcohol, and offers easier cleaning and maintenance. The instrument complies with FDA 21 CFR Part 11 and is suitable for GMP/GLP environments.
The accompanying 860 KF Thermoprep is a thermal sample preparation oven that enables analysis of substances that cannot be titrated directly because they are insoluble, reactive with KF reagent, or release water only slowly or at high temperature. The sample is weighed into a 6 mL vial, sealed with a septum, placed in the oven and heated to a preset temperature (up to 250 °C); the released water vapor is carried by dry carrier gas (built-in air pump or inert gas via inlet valve) through a heated transfer tubing into the 917 Coulometer titration cell. Applications: water determination in pharmaceuticals, APIs, polymers, plastics, petroleum products, liquids, solvents, suspensions, crystals, food products, biological materials, cosmetics.
Technical Specifications:
Method: coulometric Karl Fischer titration
Water content measuring range: 10 µg – 200 mg absolute water
Detection limit: down to 0.001 % (10 ppm)
Generator electrode: without diaphragm, SGJ 29/22
Indicator electrode: platinum (dual fused Pt ring)
Integrated components: magnetic stirrer, reagent exchange pump, touchscreen, USB interface for printer
Measuring principle: coulomb counting with in situ iodine generation
Compliance: FDA 21 CFR Part 11
Interfaces: USB (for data storage, printer, keyboard)
Type: thermal sample preparation oven for KF titration
Temperature range: up to 250 °C (control ±1 °C)
Sample vials: 6 mL (Metrohm 6.2419.007)
Carrier gas: built-in air pump or inert gas via inlet valve (N₂, dry air)
Transfer tubing: heated (prevents water condensation)
Minimum extraction time: 300 s
Compatible with any volumetric or coulometric KF titrator
Software:
VU ID: 8...
Location: BVI
Core Facility: Continuous Flow Synthesis
Equipment is operated by Personnel only: Yes
It is allowed to work with the equipment independently after familiarization with the work process on site: No
Only those with the appropriate certificate/certificate are allowed to work with the equipment: Yes
There is an opportunity to participate in equipment usage training: No
Contact Scientist (Leading Scientist): Jonas Žurauskas
Contact email address:
Information for the User:
- A briefing by the responsible person is mandatory before use. Karl Fischer reagents and solvents (methanol, imidazole, iodine, SO₂) are flammable, toxic and irritant – work in a fume hood or under adequate extraction ventilation; PPE (safety glasses, gloves, lab coat) is required. The 860 KF Thermoprep oven can reach 250 °C – avoid direct contact, and use the supplied septum-crimping tongs to insert/remove vials. Ensure a supply of dry carrier gas; regularly check the molecular sieve in the KF cell. Periodic blank determinations are mandatory to maintain accuracy. The diaphragm-free generator electrode is not suitable for samples that inhibit electrochemical reactions or oxidize iodide (for ketones/aldehydes the diaphragm version is recommended).
- Manual Coulometer
Additional Comments:
The system is suitable both for direct titration of liquid samples (injected through the septum with a syringe) and for solids, poorly soluble or slow-releasing samples via the 860 KF Thermoprep oven. The diaphragm-free configuration was selected for easier maintenance and is suitable for most analytes that are highly soluble in alcohol. 21 CFR Part 11 compliance allows use of the instrument in regulated (GMP/GLP) environments.