Sidebar

services

Audrone Valerija Kalvelyte  

Phone: +370 686 8789151 
Email:

 
Research Interests: Signaling in cell fate regulation;
Cell state-specific regulation of cell death;
Molecular mechanisms of cancer cell treatment;
Cancer and stem cell models. 
Present Position: Senior researcher (Project)
Biochemist researcher, Institute of Biochemistry 
Education:
 1993 - PhD in Natural Sciences (Biology), Vilnius University, Institute of Biochemistry, Institute of Biotechnology
1968 - MSc in Biophysics, Vilnius University, Faculty of Natural Sciences 
Experience (Past Positions): 2016–2021 - Senior researcher, Vilnius University, Life Sciences Center
2010–2016 - Senior researcher, Vilnius University, Institute of Biochemistry
1996–2010 - Senior researcher, Institute of Biochemistry
1996–2004 - Lecturer, Faculty of Natural Sciences, Vilnius University
1992–1996 - Researcher, Institute of Biochemistry
1974–1992 - Research assistant, Institute of Biochemistry
2000 - Visiting Researcher, Department of Neuroscience, Albert Einstein College of Medicine, USA
1997 - Visiting Researcher, Molecular Plant Pathology Lab., Plant Sciences Institute, Agricultural Research Service-USDA, Beltsville, USA
1979 - Visiting Trainee, Institute of Epidemiology and Micicrobiology, Moscow, Russia 
Course for MSc students in genetics "Oncogenetics" (1996–2004). Faculty of Natural Sciences, Vilnius University 
Supervision of Doctoral Students: Four doctoral dissertations were supervised.
Aurimas Stulpinas - goin on;
Natalija Krestnikova (Uralova) “Investigation of differentiated muscle-derived stem cell death and survival signalling mechanisms”. The dissertation was defended in 2013;
Daiva Baltriukienė “Identification of signalling molecules and pathways responsible for myogenic cell survival after cardiotoxic treatments“. The dissertation was defended in 2009;
Aušra Imbrasaitė “Analysis of proapoptotic and prosurvival signalling pathways induced by phorbol ester TPA in human promyelocytic leukaemia HL60 cells”. The dissertation was defended in 2004. 
Publications: LABT_LMAVB 
GoogleScholar 
Academic Cooperation: Prof. Eltyeb Abdelwahid, Northwestern University Feinberg School of Medicine, USA 
Prof. Feliksas Bukauskas, Albert Einstein College of Medicine of Yeshiva University, Rose F. Kennedy Center, USA
Prof. Robert Davis, Molecular Plant Pathology Lab.,Plant Sciences Institute, Agricultural Research Service-USDA, Beltsville, USA

Projects and Grants:

2018–2023 Lithuanian Science Projects supported by Research Council of Lithuania. Targeted Research in Smart Specialization Areas “Designing of the patient-specific, heterogeneous lung cancer cell ex vivo model system for drug efficiency prediction in personalized oncotherapy“ No. 01.2.2-LMT-K-718-01-0072, leader.
2012–2015 Research Council of Lithuania. Global grant No. VP1-3.1-ŠMM-07-K-01-103 “Molecular mechanisms of the toxicity and antitumour activity of quinones and polyphenols: enzymatic redox reactions, cytotoxicity, signal transduction and proteomics”, Habil. Dr. N. Cenas. Workpackage "Apoptotic signals in A549 cells after quinone and polyphenol treatments", leader.
2012–201 European Social Fund under National Integrated Programme: “Biotechnology and Biopharmacy: fundamental and applied research” No. VP1-3.1-SMM-08-K01-005. Action 1.1.3. Molecular processes in eukaryotic cells: the technological and medical aspects. Head of Action Prof. Dr. R. Navakauskiene. Workpackage “Anoikis mechanisms in stem and cancer cells”, leader.
2010–2011 National science program project from Lithuanian Research No. LIG-10/2010 “Prognostic Markers of Stress Kinase JNK Action for the molecular targeting in Therapy", leader.
2007–2009 Lithuanian State Science and Studies Foundation. Project of Programme Genomics and Biotechnology for the Health and Agriculture No. C07023 “Fundamental studies on Mechanisms of Stem Cell Functioning. Cytotherapy 2”, Workpackage of Institute Biochemistry “Investigation of cell death- and survival-regulating signaling mechanisms in adult organism stem cells of different commitment”, leader. 
2007 Lithuanian State Science and Studies Foundation grant No. T-46/07, "Roles of tyrosine kinase Syk in the apoptosis of stem and cancer cells", investigator.
2007–2009 Lithuanian State Science and Studies Foundation. Project of Development of High Technologies Programme No. B-07041 “Development of the models to regenerate heart structures employing stem and specialized cells also biological tissues“, investigator.
2006–2008 Improving the skills of scientists and researchers in the field of stem and later differentiation cell research and applications (Contract No. ESF/2004/2.5.0-K01-035/SUT-179), investigator.
2004–2006 Lithuanian Science and Studies Foundation grant No. U-04/2001. "Stem cell integration, survival and functional efficiency of stem cells in the pathological lesion. Preclinical study, Cytotherapy", Workpackage of Institute Biochemistry “Determination of signalling molecules in death/survival pathway and establishment of genetically modified apoptosis resistant transplantable myogenic stem cells”, leader. 
2006 Lithuanian State Science and Studies Foundation grant No. T-32/06, "The role of tyrosine kinase Syk in the differentiation and apoptosis of various leukemic cell lines", investigator.
2003–2006 Lithuanian State Science and Studies Foundation project of the "Program of the priorities of Lithuanian research and experimental development", "Regularities of mycotoxin accumulation in food and development of preventive safety measures" No. C-03003, investigator. 
2000–2002 Lithuanian State Science and Studies Foundation. Complex grant No. K-024 "Perspectives of Gene Therapy in Oncology". Partner - Lithuanian Oncology Centre, leader. 
2000–2001 US National Research Council Twinning program with Estonia, Latvia and Lithuania. Partner - Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University (USA). Lithuanian part of the project "The role of gap junctions in the regulation of apoptosis", leader.
1996–2001 State research programme "Molecular foundations of biotechnology: gene structure, function and regulation of gene expression", Grant "Role of proto-oncogenes in the regulation of eukaryotic cell differentiation and apoptosis", leader. 
1987–1990 USSR Scientific Program "Human Genome", grant manager.
Research Dissemination:

Lithuanian radio, TV, Lithuanian newspapers
Other Related Activities: 2015–present Member of Lithuanian Stem Cell Research Association
2010–present Member of Lithuanian Biochemical Society
2003–2013 Member Lithuanian Biophysics Club
1995–2008 Member of Scientific Council of the Institute of Biochemistry
1996–2001 Member of Scientific Council of the State Research Program "Molecular basis of biotechnology: gene structure, function and regulation of gene expression".
Management of RCL-initiated student practice
Member of the examination commission for the doctoral program "Cellular molecular biology", Vilnius University
Member of the council for the defense of the doctoral theses
Participation in the preparation and implementation of EU structural funds projects
Acting head of the Developmental Biology Laboratory, 1997 
Languages: Lithuanian (native), English, Russian

 

Research

Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies. More information